Pregabalin, Gabapentin
Posted On February 18, 2020
Gaba Analog
- used with opiod may cause respiratory suppression
Pregabalin (Lyrica)
- Caution when used with opioid and benzo
- Excreted from urine 90% unchanged
- Pregnancy: category C
- Pregabalin Capsule: 25, 50, 75, 100, 150, 200, 225, 300 mg (generic about $30 for 60 cap)
- Pregabalin solution: 20 mg/ml
- Lyrica CR: 82.5, 165, 330 mg ( no generic, $400 for 30 tab)
- Indications:
- Fibromyalgia, neuropathic pain, seizure
- Off label use:
- Chronic cough, anxiety, pruritus, Restless Leg Syndrome, vasomotor w menopause
Gabapentin (Neurontin)
- Start dose: 100 to 300 mg hs
- Target dose: 300 mg to 600 mg qid
- Max dose: aournd 3,600 mg per day
- Available in: 100, 300, 400, 600, 800 mg (Generic < $20 per month supply)
- Indications:
- neuropathic pain
- alcohol withdraw
- Off label use
- fibromyalgia
- hiccup
- pruritis
- Post op pain
- restless leg
- anxiety disorder
- vasomotor symptoms with menopause
- Kidney disease
- take bid or qd, reduce dose
- end stage renal disease: up to 300 mg /day