Aducanumab
approved by FDA for mild Alzheimer’s disease: uncertain as to which patients may benefit A recombinant monoclonal antibody reduce amyloid plaque on pet imaging Coverage: not covered by public & private payers Cost: about $60,000 per year, depends on weight inconsistant clinical effects on rating scales Dosing MRI brain...
Parkinson
Medication induced usually symmetrical take pt off the offending medication can be caused by older neuroleptic and Metoclopropamide (Reglan) May use anticholinergic for treatment Idiopathic: one side is worse than other. For young onset (<65 years old). start with dopamine agonist, such as ropinirole Older patient, use L dopa...