SNRI Serotonin-Norepihephrine reuptake inhibitor Little or no cholinergic or histaminergic effect Duloxetine, Venlafaxine, Desyenlafaxine has more inhibition of Serotonin uptake. Levomilnacipran preferentially block reuptake of norepinephrine Duloxetine (Cymbalta) Highly protein bound Mainly cleared by liver, <1% excreted in urine. Avoid in liver disease, and CrCl <30 Available in generic...